Mesenchymal Stem Cells: Intrinsic/Extrinsic Factors Regulating Stemness, Growth, and Differentiation

Mesenchymal stem/stromal cells (MSCs) are adult stem cells with the capability of self-renewal and multilineage differentiation into skeletal and/or mesodermal tissues, including bone, fat, cartilage, and muscle tissues.

Bone marrow has been the primary site for obtaining MSCs, but recent studies have indicated that MSCs are also present at other tissue sites, including adipose, muscle, skin, liver, umbilical cord, tonsil, and blood tissue, and even in urine samples, all of which play a role in regenerating damaged tissues or regulating inflammation or other undiscovered functions.

Approximately 50 years have passed since MSC-like cells were first discovered, and many studies have been carried out to outline the characteristics of MSCs and to investigate their potential therapeutic implications in regenerative medicine and immunomodulation. However, only a few have successfully managed to reach clinical availability, implying that we probably do not yet have a full understanding of the biology of MSCs.

For this Special Issue, we invite authors/experts to submit high-quality original research articles that further expand our knowledge of and provide us with insights into MSCs. We are particularly interested in studies illustrating intrinsic/extrinsic cellular and molecular factors regulating stemness, growth, and differentiation of tissue-specific MSCs as well as their potential implications for tissue engineering and regenerative medicine.

Prof. Inho Jo
Dr. Steve (Se-Young) Oh
Dr. Federica Facchin

The submission deadline is 15 September 2022. Papers may be submitted immediately or at any point until 15 September 2022, as accepted papers will be published on an ongoing basis. For more information on this Special Issue and submission guidelines, please visit the following page: https://www.mdpi.com/journal/cells/special_issues/Mesenchymal_Stem_Cells_Stemness_Growth_Differentiation