Exploring the Role of SPP1 in Macrophage-Osteogenic Cell Crosstalk and its Involvement in Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva
Post-doctoral research fellowship available at the University of Milano-Bicocca
The research group led by Prof. Silvia Brunelli at the School of Medicine and Surgery, University of Milano-Bicocca, is seeking a highly motivated Post-Doctoral Research Fellow to join an exciting and ambitious project funded by Fondazione Telethon.
Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital disorder characterized by abnormal bone formation (heterotopic ossification, HO) in ligaments, tendons, and skeletal muscles. FOP is caused by gain-of-function mutations in the ACVR1 gene, which dysregulate the bone morphogenetic protein (BMP) signaling pathway.
Methodologies: The project will take advantage of transgenic murine model of FOP and incorporate state-of-the-art techniques, including CRISPR/Cas9-based genome editing, genome-wide transcriptomic analysis in vitro and in vivo assays,
Candidate Profile: We are looking for highly motivated researchers with a PhD in Biology, Biotechnology, Biomedical Sciences, or related fields.
Desired qualifications and skills:
- Experience in cell and molecular biology
- Expertise in murine models
- Proficiency in bioinformatics and data analysis (including R programming)
- Familiarity with any of the above-mentioned techniques will be considered an advantage
Position Details:
Start date: April 1st, 2024
Duration: 1 year (renewable for an additional year)
How to Apply
Interested candidates should send the following documents to Prof. Silvia Brunelli at silvia.brunelli@unimib.it
